上海交通大学博士、访问学者，福建省引进高层次人才。从事基于计算系统生物学的蛋白质动态结构与互作网络研究，以及在酶催化机理与药物筛选等领域的应用，包括PTM功能效应预测、蛋白聚集调控及靶标构象变化模拟等。目前已在Advanced Science、Chemical Engineering Journal、Green Chemistry和Journal of Hazardous Materials等国际知名期刊发表SCI论文25篇（中科院1区12篇，中科院2区8篇）；授权2项发明专利和5项软件著作权；主持国家自然科学基金青年科学基金、福建省人社厅高层次人才和青年优秀人才培养资助项目、福州大学新进教师科研启动基金等项目。
PTMint is a manually curated database of experimental evidence for PTMs modulating protein-protein interactions across multiple organisms, integrating 2,477 PTM sites and 2,371 PPI pairs associated with 357 diseases. It provides comprehensive annotations to support understanding of PTM-mediated PPI regulation in disease and drug discovery.
PhosPPI is a sequence-based machine learning predictor for phosphorylation effects on PPIs, requiring no structural input and achieving superior accuracy and AUC. Users submit protein sequences and phosphorylation sites to obtain predictions of enhanced, inhibited, or no effect.
PTMPhaSe is a curated database of PTM regulation on liquid-liquid phase separation (LLPS), covering 733 PTM sites in 164 proteins across 14 organisms and integrating sequence, structural, and PPI annotations. It also offers human proteome-scale predictions of functional phosphorylation sites regulating LLPS, aiding research in PTM-regulated LLPS and disease.
PhosLLPS is a Transformer-based graph neural network predictor for identifying phosphorylation sites that regulate LLPS, achieving an AUC of 0.9116. Users can input protein sequences and designated sites to obtain rapid predictions, complementing the PTMPhaSe database.
项目角色：主持
项目角色：主持
项目角色：主持
项目角色：主持
项目角色：参与
Fumarate-Based Copolyesters with Long-Term Stability and Temperature-Gated Enzymatic Degradation.
Journal of Hazardous Materials, 2026, 143008
Enhanced brain delivery of oleanolic acid by GSH-PEGylated liposomes and its amelioration of scopolamine-induced cognitive dysfunction via multi-target regulation.
International Journal of Pharmaceutics-X, 2026, 100509
Stereoselective synthesis of (S)-3-Hydroxy-3-phenylpropionate with a novel carbonyl reductase identified from a soda lake metagenome.
International Journal of Biological Macromolecules, 2026, 149193
Deep learning model of post-translational modification regulating liquid-liquid phase separation.
Communications Chemistry, 2025, 393
DynaRNA: accurate dynamic RNA conformation ensemble generation with diffusion model.
Communications Biology, 2025, 1472
Cell Cycle of Trypanosoma epinepheli bloodstream forms in vivo and in vitro.
Current Zoology, 2025, zoaf067
Accurate Generation of Conformational Ensembles for Intrinsically Disordered Proteins with IDPFold.
Advanced Science, 2025, e11636
Cell membrane-inspired controllably degradable polyesters: High barrier and tailored oxidation responsiveness.
Chemical Engineering Journal, 2025, 169264
AI-Driven De Novo Design of Ultra Long-Acting GLP-1 Receptor Agonists.
Advanced Science, 2025, e07044
Design of environmentally degradable polyethylene-like polyesters and eco-friendly recycling via commercial enzymes.
Green Chemistry, 2025, 27, 6660-6675
Drude2019IDPC polarizable force field reveals structure-function relationship of insulin.
International Journal of Biological Macromolecules, 2024, 136256
Excited-Ground State Transition of RNA Strand Slippage Mechanism Captured by Base-specific Force Field.
Journal of Chemical Theory and Computation, 2024, 6082-6097
Single-cell enzymatic cascade synthesis of testolactone enabled by engineering of polycyclic ketone monooxygenase and multi-gene expression fine-tuning.
International Journal of Biological Macromolecules, 2024, 133229
Reproductive chemical database: a curated database of chemicals that modulate protein targets regulating important reproductive biological processes.
Cell & Bioscience, 2024, 73
Early Aggregation Mechanism of SOD128-38 Based on Force Field Parameter of 5-Cyano-Tryptophan.
Journal of Chemical Information and Modeling, 2024, 3942-3952
Multiplex metabolic pathway engineering of Monascus pilosus enhances lovastatin production.
Applied Microbiology and Biotechnology, 2023, 6541-6552
Improved antimicrobial activity of bovine lactoferrin peptide (LFcinB) based on rational design.
Protein Journal, 2023, 633-644
Sequence-based Machine Learning Method for Predicting the Effects of Phosphorylation on Protein-Protein Interactions.
International Journal of Biological Macromolecules, 2023, 125233
Identification and validation of new MADS-box homologous genes in 3010 rice pan-genome.
Plant Cell Reports, 2023, 4975-988
Phosphorylation Regulation Mechanism of β2 Integrin for the Binding of Filamin Revealed by Markov State Model.
Journal of Chemical Information and Modeling, 2023, 605-618
PTMint database of experimentally verified PTM regulation on protein–protein interaction.
Bioinformatics, 2023, btac823
Databases and Bioinformatic Tools for Glycobiology and Glycoproteomics.
International Journal of Molecular Sciences, 2020, 6727-6727
The effect of normal human serum on mouse trypanosome Trypanosoma musculi in vitro and in vivo.
Experimental Parasitology, 2018, 115-120
PCR-based identification of Trypanosoma lewisi and Trypanosoma musculi using maxicircle kinetoplast DNA.
Acta Tropica, 2017, 207-212
Current status of Clonorchis sinensis and clonorchiasis in China.
Transactions of the Royal Society of Tropical Medicine and Hygiene, 2016, 21–27